Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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First detection of Leishmania donovani in sand flies from Cameroon and its epidemiological implications
Filename | 327. Ngouateu Tateng et al., First det. Leishm. donovani,TropMedIntH2018.pdf |
Filesize | 531.50 KB |
Version | o.327 |
Date added | June 13, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | Cameroon, Leishmania donovani, Sand flies, visceral leishmaniasis |
Authors | Ngouateu Tateng, A., Kirstein, O. D., Ngouateu, O. B., Krüger, A., von Stebut, E., Maurer, M., Payne, V. K., Warburg, A., and Dondji, B. |
Citation | Ngouateu Tateng, A., Kirstein, O. D., Ngouateu, O. B., Krüger, A., von Stebut, E., Maurer, M., Payne, V. K., Warburg, A., and Dondji, B.: First detection of Leishmania donovani in sand flies from Cameroon and its epidemiological implications. Trop. Med. Int. Health 2018: 23; 1014-1021. |
Corresponding authors | Dondji, B. |
DocNum | O.327 |
DocType | |
Edition; Page | 23; 1014-1021 |
IF | 2.42 |
Publisher | Trop. Med. Int. Health |
ReleaseDate | 2018 |
Objectives: A sound knowledge of the vector-host-parasite transmission dynamics is a prerequisite for adequate control measures of vector-borne diseases. To achieve this, an entomological investigation was conducted in the cutaneous leishmaniasis (CL) endemic focus of Mokolo District, northern Cameroon to identify the insect vector(s) of the disease.
Methods: Phlebotomine sand flies were collected in and around Mokolo using New Standard CDC Miniature Light Traps. Individual sand flies were used for morphological species identification, and the remainder of the body for DNA analysis. Sand flies were demonstrated to harbour Leishmania spp. parasites using ITS1 PCR. Mitochondrial vertebrate-specific Cytochrome b -PCR was used to identify blood meals ingested by female sand flies. PCR amplicons were sequenced for Leishmania and blood sources discrimination.
Results: This study revealed the presence of Leishmania donovani complex DNA (n = 1) in Phlebotomus duboscqi and of lizard-borne Leishmania tarentolae-like DNA (n = 3) in Sergentomyia spp. in 79 sand fly specimens from Mokolo district.
Conclusions: The causative agent of CL could not be detected in potential vectors. Instead, we found evidence for visceral leishmaniasis (VL) parasites in Phlebotomus duboscqi as well as enzootic reptile parasites in the Mokolo area. We recommend that an epidemiological survey be carried out in the area to evaluate the prevalence and eventually describe the clinical manifestations of VL in the human population. Political instability in neighbouring countries and the resulting refugee migration are likely explanations for the emergence of VL in Mokolo.
(Last update: 09.2024)
Number of original publications in peer-reviewed journals: | 626 |
Number of reviews in peer-reviewed journals: | 221 |
Number of publications (original work and reviews) in peer-reviewed journals: | 847 |
Cumulative IF for original publications in peer-reviewed journals: | 4432.59 |
Cumulative IF for reviews in peer-reviewed journals: | 1648.22 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 6080.81 |
Total number of citations: 38,608, h-index: 99 (Web of Science September 2024) | 38,608 |
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