Publications
Publications, Books, Book Chapters and Reviews by Prof. Marcus Maurer, MD
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Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4
Filename | 175. Nelissen et al., MC protect spinal cord damage NEUROBIOLOGY 2013.pdf |
Filesize | 1.66 MB |
Version | o.175 |
Date added | June 6, 2020 |
Downloaded | 0 times |
Category | Original Work |
Tags | IL-10, IL-13, IL-6, Inflammation, mast cell, MCP-1, mMCP4, Spinal cord injury, TNF-α |
Authors | Nelissen, S., Vangansewinkel, T., Geurts, N., Geboes, L., Lemmens, E., Vidal, P. M., Lemmens, S., Willems, L., Boato, F., Dooley, D., Pehl, D., Pejler, G., Maurer, M. Metz, M., and Hendrix, S. |
Citation | Nelissen, S., Vangansewinkel, T., Geurts, N., Geboes, L., Lemmens, E., Vidal, P. M., Lemmens, S., Willems, L., Boato, F., Dooley, D., Pehl, D., Pejler, G., Maurer, M. Metz, M., and Hendrix, S.: Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4. Neurobiol. Dis. 2013: 62C; 260-272. |
Corresponding authors | Hendrix, S. |
DocNum | o.175 |
DocType | |
Edition; Page | 62C; 260-272 |
IF | 5.20 |
Publisher | Neurobiol. Dis. |
ReleaseDate | 2013 |
Mast cells (MCs) are found abundantly in the central nervous system and play a complex role in neuroinflammatory diseases such as multiple sclerosis and stroke. In the present study, we show that MC-deficient KitW-sh/W-sh mice dis- play significantly increased astrogliosis and T cell infiltration as well as significantly reduced functional recovery after spinal cord injury compared to wildtype mice. In addition, MC-deficient mice show significantly increased levels of MCP-1, TNF-α, IL-10 and IL-13 protein levels in the spinal cord. Mice deficient in mouse mast cell protease 4 (mMCP4), an MC-specific chymase, also showed increased MCP-1, IL-6 and IL-13 protein levels in spinal cord samples and a decreased functional outcome after spinal cord injury. A degradation assay using supernatant from MCs derived from either mMCP4−/− mice or controls revealed that mMCP4 cleaves MCP-1, IL-6, and IL-13 suggest- ing a protective role for MC proteases in neuroinflammation. These data show for the first time that MCs may be protective after spinal cord injury and that they may reduce CNS damage by degrading inflammation-associated cytokines via the MC-specific chymase mMCP4
(Last update: 09.2024)
Number of original publications in peer-reviewed journals: | 626 |
Number of reviews in peer-reviewed journals: | 221 |
Number of publications (original work and reviews) in peer-reviewed journals: | 847 |
Cumulative IF for original publications in peer-reviewed journals: | 4432.59 |
Cumulative IF for reviews in peer-reviewed journals: | 1648.22 |
Cumulative IF of publications (original work & reviews) in peer-reviewed journals: | 6080.81 |
Total number of citations: 38,608, h-index: 99 (Web of Science September 2024) | 38,608 |
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